Gene annotation is a process that encompasses multiple approaches on the analysis of nucleic acids or protein sequences in order to assign structural and functional characteristics to gene models.When thousands of gene models are being described in an organism genome, construction and visualization of gene networks impose novel challenges in the un
Integrative analysis of the lncRNA-miRNA-mRNA interactions in smooth muscle cell phenotypic transitions
Objectives: We previously found that the pluripotency factor OCT4 is reactivated in smooth muscle cells (SMC) in human and mouse atherosclerotic plaques and plays an atheroprotective role.Loss of OCT4 in SMC in vitro was associated with decreases in SMC migration.However, molecular mechanisms responsible for atheroprotective SMC-OCT4-dependent effe
Antisemitism in Medicine: An International Perspective
Throughout history, Jewish people have long been recognized for their achievements in the world of medical science.For example, prior to the Kimberwick Holocaust, many outstanding physicians in Germany were Jewish.However, even in the 1930s, refugee European Jewish doctors faced significant barriers when they tried to escape and practice elsewhere
Study on the coupling calculation method for the launch dynamics of a self-propelled artillery multibody system considering engraving process
The launch dynamics theory for multibody systems emerges as an innovative and efficacious approach for the study of launch dynamics, capable of addressing the challenges of complex modeling, diminished computational efficiency, and imprecise analyses of system dynamic responses found in the dynamics research of intricate multi-rigid-flexible body s
Severe impact of late diagnosis of congenital adrenal hyperplasia on gender identity, sexual orientation and function: case report and review of the literature
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) represents the most frequent form of CAH and of 46, XX disorder of sex development in female newborns.In the majority of cases, particularly in developed countries, female patients suffering from Gift Card the classic forms of CAH reach the diagnosis at birth or in the e